β-catenin-IN-8
β-catenin-IN-8 (Compound 25) is a β-catenin inhibitor. β-catenin-IN-8 inhibits β-catenin and c-Myc protein levels, and inhibits Wnt-target genes level (Fgf20 and Sall4) . β-catenin-IN-8 has colorectal cancer anticancer activities, and has metabolic stability[1].
Product Specifications
CAS Number
259130-14-8
UNSPSC
12352005
Target
C-Myc; Wnt; β-catenin
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/β-catenin-in-8.html
Smiles
O=S(C1=CC=C(Cl)C=C1)(NC2=CC=C(N3C=CN=C3)C=C2)=O
Molecular Formula
C15H12ClN3O2S
Molecular Weight
333.79
References & Citations
[1]Puxeddu M, et al. Development of N- (4- (1H-Imidazol-1-yl) phenyl) -4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of β-Catenin with Enhanced Antitumor Activity and Metabolic Stability. J Med Chem. 2024 Nov 28;67 (22) :20298-20314.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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