M-1211
M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression[1].
Product Specifications
CAS Number
[2377337-93-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m-1211.html
Purity
99.29
Solubility
DMSO : 7.69 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC(C(CN2CCC2)([C@@]3([H])CCC[C@@H]3NC(OC)=O)C4CCN(CC5(OC)CN(C6=CC=C(S(N7C[C@@]8([H])N(C(C=C)=O)C[C@@]7(C8)[H])(=O)=O)C=C6)C5)CC4)=CC=C1
Molecular Formula
C42H57FN6O6S
Molecular Weight
793.00
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang M, et al. Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression. J Med Chem. 2021;64 (14) :10333-10349.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS962646-01 0.02 mg (E-Coli)
Recombinant Human 5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)
Ask
View Details