(R) -Reticuline

(R) -Reticuline is an isomer of Reticuline (HY-N1356) . Reticuline displays anti-inflammatory and cardiovascular effects through JAK2/STAT3 and NF-κB signaling pathways. Salutaridine is a key intermediate in morphine biosynthesis. Salutaridine can be converted from (R) -Reticuline in the poppy plant. The conversion system relies on membrane-bound cytochrome P-450 enzymes and also requires reducing cofactors NADPH, molecular oxygen, etc[1][2].

Product Specifications

CAS Number

[3968-19-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Cytochrome P450

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/r-reticuline.html

Purity

99.41

Solubility

10 mM in DMSO

Smiles

OC1=CC2=C(C=C1OC)CCN(C)[C@@H]2CC3=CC=C(OC)C(O)=C3

Molecular Formula

C19H23NO4

Molecular Weight

329.39

Precautions

H302, H315, H319

References & Citations

[1]Gerardy R, et al. Formation of salutaridine from (R) -reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum[J]. Phytochemistry, 1992, 32 (1) : 79-86.|[2]Yang X, et al. Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways. Planta Med. 2018 Jan;84 (1) :20-25.