(-) -Irofulven
(-) -Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-) -Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity[1][2].
Product Specifications
CAS Number
158440-71-2
Product Name Alternative
MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863
UNSPSC
12352211
Target
Apoptosis; DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/minus-irofulven.html
Purity
98.86
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C1(CC1)[C@@](O)(C2=O)C)=C3C2=CC(C)=C3CO
Molecular Formula
C15H18O3
Molecular Weight
246.31
References & Citations
[1]Yutian Wang, et al. Irofulven induces replication-dependent CHK2 activation related to p53 status. Biochem Pharmacol. 2007 Feb 15;73 (4) :469-80.|[2]H S Friedman, et al. Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice. Cancer Chemother Pharmacol. 2001 Nov;48 (5) :413-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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