(-) -Irofulven

(-) -Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-) -Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity[1][2].

Product Specifications

CAS Number

[158440-71-2]

Product Name Alternative

MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863

UNSPSC

12352211

Target

Apoptosis; DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/minus-irofulven.html

Purity

98.86

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C1(CC1)[C@@](O)(C2=O)C)=C3C2=CC(C)=C3CO

Molecular Formula

C15H18O3

Molecular Weight

246.31

References & Citations

[1]Yutian Wang, et al. Irofulven induces replication-dependent CHK2 activation related to p53 status. Biochem Pharmacol. 2007 Feb 15;73 (4) :469-80.|[2]H S Friedman, et al. Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice. Cancer Chemother Pharmacol. 2001 Nov;48 (5) :413-6.