Vapitadine (hydrochloride)
Vapitadine hydrochloride (Compound 3a) is a selective, orally active and nonsedating antihistamine agent, which exhibits a good binding affinity with human cloned histamine H1 receptor with a Ki of 19 nM. Vapitadine hydrochloride decreases the histamine-induced lethality (ED50 is 0.056-1.2 mg/kg), antagonizes the cutaneous reactions to histamine (ED50 is 0.51-1.4 mg/kg) in rats[1].
Product Specifications
CAS Number
279253-83-7
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vapitadine-hydrochloride.html
Smiles
O=C(C1=CN=C2N1CCC3=CC=CC=C3C24CCNCC4)N.Cl.Cl
Molecular Formula
C17H22Cl2N4O
Molecular Weight
369.29
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor
Available Sizes
Frequently Asked Questions
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