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EGFR-IN-98

EGFR-IN-98 (Compound 4c) is a EGFR inhibitor. The IC50 values of L858R/T790M/C797S and Del19/T790M/C797S are 0.277 μM and 0.089 μM, respectively. EGFR-IN 98 can be used in the study of tumors[1].

Product Specifications

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-98.html

Purity

99.12

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC=C(O)C(C2=NC3=C(C=CC=C3)C(NCCN4CCNCC4)=N2)=C1

Molecular Formula

C20H22ClN5O

Molecular Weight

383.87

References & Citations

[1]Chang H, et al. Machine Learning-Based Virtual Screening and Identification of the Fourth-Generation EGFR Inhibitors. ACS Omega, 2024.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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