(RS) -G12Di-1
(RS) -G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D[1].
Product Specifications
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rs-g12di-1.html
Solubility
10 mM in DMSO
Smiles
C#CC1=CC=CC2=CC=CC(C3=C(C4=C(C(N5CC6CCC(N6C(C7CC(O7)=O)=O)C5)=NC(OCC89CCCN8CCC9)=N4)C=N3)F)=C12
Molecular Formula
C37H35FN6O4
Molecular Weight
646.71
References & Citations
[1]Zheng Q, et al. Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nat Chem Biol. Published online March 5, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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