SB02024
Product Specifications
UNSPSC Description
SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity[1][2][3].
Target Antigen
CXCR; PI3K; STAT
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation;JAK/STAT Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sb02024.html
Purity
99.7
Solubility
10 mM in DMSO
Smiles
O=C1C=C(N2[C@H](C)COCC2)C=C(N3[C@@H](C(F)(F)F)CCCC3)N1
Molecular Weight
345.36
References & Citations
[1]Noman MZ, et al. Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy. Sci Adv. 2020 Apr 29;6(18):eaax7881.|[2]Yu Y, et al. Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol. 2024 Mar 20.|[3]Bassam Claude JANJI, et al. Biomarker. Patent WO2020008046 A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122891/SB02024-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122891/SB02024-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2126737-28-6
Available Sizes
Curated Selection
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