Isepamicin (sulfate)

Isepamicin sulfate (Sch 21420 sulfate) is a broad-spectrum aminoglycoside antibiotic. Isepamicin sulfate has considerable antimicrobial activity against some Gram-negative non-fermenting bacteria that are highly resistant to antibiotics. Isepamicin sulfate inhibits writhing reactions induced by Acetic acid (HY-Y0319), regulates vascular blood flow and blood pressure, and inhibits spontaneous uterine movements. Isepamicin sulfate has antidiuretic and blood sugar-raising effects. Isepamicin sulfate can be used in seizure research[1][2].

Product Specifications

CAS Number

[67814-76-0]

Product Name Alternative

Sch 21420 (sulfate)

UNSPSC

12352211

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/isepamicin-sulfate.html

Purity

98.0

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=S(O)(O)=O.O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CN)=O)O[C@](OC[C@](C)(O)[C@@H]3NC)([H])[C@@H]3O.[x]

Molecular Formula

C22H43N5O12.xH2SO4

References & Citations

[1]Samonis G, et al. Antimicrobial susceptibility of non-fermenting Gram-negative isolates to isepamicin in a region with high antibiotic resistance. Eur J Clin Microbiol Infect Dis. 2012 Nov;31 (11) :3191-8.|[2]Shibata K, et al. [General pharmacological studies on isepamicin sulfate (HAPA-B) ]. Jpn J Antibiot. 1987 Jan;40 (1) :145-69.