Rhesus macaque CA125 / MUC16 (13647-14291) Protein, His Tag (MALS verified)

The CA125, also known as the MUC16, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. The CA 125 molecule is almost certainly a glycoprotein with a predominance of O-linkages. It is heterogeneous with regard to both size and charge, most likely due to continuous deglycosylation of side chains during its life-span in bodily fluids. It exists as a very large complex (perhaps as much as 4 million daltons) under natural conditions.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73.9 kDa. The protein migrates as 95-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

XP_015296314.1

Expression Region

Pro 13647 - Pro 14291

Host

HEK293

Target

CA125

Conjugation

Unconjugated

Tag

C-10xHis

Source

Rhesus macaque

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

0.1 EU per μg

Purity

95%

Bioactivity

Immobilized Rhesus macaque CA125 (13647-14291), His Tag (Cat. No. CA5-R52H6) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Mesothelin, Fc,Avitag (Cat. No. MSN-H82F6) with a linear range of 0.002-0.313 μg/mL (QC tested).