MA-0204

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD) [1].

Product Specifications

CAS Number

[2095128-17-7]

Product Name Alternative

GMX1778 (nicotinate),GMX1777; EB-1627

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/MA-0204.html

Purity

99.31

Solubility

DMSO : 43.33 mg/mL (ultrasonic)

Smiles

O=C(C[C@@H](CCCOC1=CC=CC=C1CN2C(C)=CN=C2C3=CC=C(C=C3)OC(F)(F)F)C)O

Molecular Formula

C25H27F3N2O4

Molecular Weight

476.49

References & Citations

[1]Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD) . ACS Med Chem Lett. 2018 Jul 31;9 (9) :935-940.