FT709
FT709 is a potent and selective USP9X inhibitor, an IC50 of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms[1].
Product Specifications
CAS Number
[2413991-74-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Deubiquitinase; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ft709.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CN=C2C(OCCO2)=C1)(N3CC(CN(C([C@@H](O)C4=CC=CC5=C4N=C(C)O5)=O)C6)=C6C3)=O
Molecular Formula
C23H22N4O7S
Molecular Weight
498.51
Precautions
H302, H315, H319
References & Citations
[1]Clancy A, et, al. The deubiquitylase USP9X controls ribosomal stalling. J Cell Biol. 2021 Mar 1;220 (3) :e202004211.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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