AZD8329

AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3[1].

Product Specifications

CAS Number

[1048668-70-7]

UNSPSC

12352005

Target

11β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/azd8329.html

Concentration

10mM

Purity

99.74

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=C(N2N=CC(C(NC3C(C4)CC5CC4CC3C5)=O)=C2C(C)(C)C)C=C1

Molecular Formula

C25H31N3O3

Molecular Weight

421.53

References & Citations

[1]Scott JS, et al. Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4- (2-adamantylcarbamoyl) -5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329) . J Med Chem. 2012 Nov 26;55 (22) :10136-47.