Preladenant
Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.
Product Specifications
CAS Number
377727-87-2
Product Name Alternative
SCH-420814
UNSPSC
12352005
Hazard Statement
H302
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Preladenant.html
Purity
99.82
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
NC1=NC(N(CCN2CCN(C3=CC=C(OCCOC)C=C3)CC2)N=C4)=C4C5=NC(C6=CC=CO6)=NN51
Molecular Formula
C25H29N9O3
Molecular Weight
503.56
Precautions
H302
References & Citations
[1]Hodgson RA, et al. Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2- (2-furanyl) -7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent|[2]Hodgson RA, et al. Preladenant, a selective A (2A) receptor antagonist, is active in primate models of movement disorders. Exp Neurol. 2010 Oct;225 (2) :384-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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