Preladenant

Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.

Product Specifications

CAS Number

[377727-87-2]

Product Name Alternative

SCH-420814

UNSPSC

12352005

Hazard Statement

H302

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Preladenant.html

Purity

99.82

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

NC1=NC(N(CCN2CCN(C3=CC=C(OCCOC)C=C3)CC2)N=C4)=C4C5=NC(C6=CC=CO6)=NN51

Molecular Formula

C25H29N9O3

Molecular Weight

503.56

Precautions

H302

References & Citations

[1]Hodgson RA, et al. Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2- (2-furanyl) -7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent|[2]Hodgson RA, et al. Preladenant, a selective A (2A) receptor antagonist, is active in primate models of movement disorders. Exp Neurol. 2010 Oct;225 (2) :384-90.