HPK1-IN-53
HPK1-IN-53 (compund 3a) is the potent HPK1 inhibitor (IC50=48 nM) [1].
Product Specifications
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-53.html
Smiles
O=C(NC1CCN(C)CC1)NC2=C(OCC)C=C(N=CC(C#N)=C3NC4=CC(OC)=C(Cl)C=C4Cl)C3=C2
Molecular Formula
C26H28Cl2N6O3
Molecular Weight
543.44
References & Citations
[1]Chen L, et al. Design, synthesis, and biological evaluation of novel HPK1 inhibitors possessing 3-cyano-quinoline moiety. Bioorg Chem. 2024 Dec;153:107814.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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