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HPK1-IN-53

HPK1-IN-53 (compund 3a) is the potent HPK1 inhibitor (IC50=48 nM) [1].

Product Specifications

UNSPSC

12352005

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hpk1-in-53.html

Smiles

O=C(NC1CCN(C)CC1)NC2=C(OCC)C=C(N=CC(C#N)=C3NC4=CC(OC)=C(Cl)C=C4Cl)C3=C2

Molecular Formula

C26H28Cl2N6O3

Molecular Weight

543.44

References & Citations

[1]Chen L, et al. Design, synthesis, and biological evaluation of novel HPK1 inhibitors possessing 3-cyano-quinoline moiety. Bioorg Chem. 2024 Dec;153:107814.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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