FSC231

FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects[1].

Product Specifications

CAS Number

[1215849-96-9]

Product Name Alternative

PK-8165,PK-8165 (hydrochloride),ICI 55897; Clobuzarit

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fsc231.html

Purity

99.84

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(OCC)NC(/C(C#N)=C/C1=CC=C(Cl)C(Cl)=C1)=O

Molecular Formula

C13H10Cl2N2O3

Molecular Weight

313.14

References & Citations

[1]Zhang X, et al. FSC231 alleviates paclitaxel-induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK-3β and ERK1/2. Brain Behav. 2021 Nov;11 (11) :e2380. |[2]Thorsen TS, et al. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proc Natl Acad Sci U S A. 2010 Jan 5;107 (1) :413-8. |[3]Cai Fei, et al. GW27-e1146 PICK1 inhibition restores myocardial injury by suppressing reactive oxygen species generation and apoptosis in diabetic rats. J Am Coll Cardiol. 2016 Oct, 68 (16_Supplement) C67.