Vicine

Vicine, an alkaloid glycoside found mainly in fava beans, is toxic in individuals who have a hereditary loss of the enzyme glucose-6-phosphate dehydrogenase and may cause haemolytic anaemia.Vicine is an inactive compound that is hydrolysed by the intestinal microflora to a highly reactive free radical generating compound, the aglycone divicine when Vicine enters the body through food[1][2][3][4].

Product Specifications

CAS Number

[152-93-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Drug Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vicine.html

Purity

99.79

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N=C(N)NC(N)=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O

Molecular Formula

C10H16N4O7

Molecular Weight

304.26

Precautions

H302

References & Citations

[1]Farran MT, et al. Vicine and convicine in common vetch (Vicia sativa) seeds enhance beta-cyanoalanine toxicity in male broiler chicks. Int J Toxicol. 2002 May-Jun;21 (3) :201-9.|[2]Lattanzio V, et al. Variability of amino acids, protein, vicine and convicine in Vicia faba (L) cultivars[J]. Journal of Food Science, 1983, 48 (3) : 992-993.|[3]Liener IE. Toxic constituents of plant foodstuffs. Proc Nutr Soc. 1970 May;29 (1) :56-7. |[4]Khazaei H, et al. Eliminating vicine and convicine, the main anti-nutritional factors restricting faba bean usage[J]. Trends in Food Science & Technology, 2019, 91: 549-556.