RCM-1

RCM-1 is a forkhead box M1 (FOXM1) inhibitor with an EC50 of 0.72 μM in U2OS cells. RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1. RCM-1 can be used for asthma and other chronic airway diseases research[1].

Product Specifications

CAS Number

[339163-65-4]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RCM-1.html

Purity

98.56

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

N#CC1=C(C2=CC=CS2)C=C(C3=CC=CS3)N=C1SCC(C4=CC=CS4)=O

Molecular Formula

C20H12N2OS4

Molecular Weight

424.58

Precautions

H315, H319

References & Citations

[1]Lifeng Sun, et al. The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci Signal. 2017 Apr 18;10 (475) :eaai8583.