Octinoxate
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo[1][2][3][4][5].
Product Specifications
CAS Number
5466-77-3
Product Name Alternative
Octyl methoxycinnamate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor; Cytochrome P450; Estrogen Receptor/ERR; Thyroid Hormone Receptor
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Octinoxate.html
Concentration
10mM
Purity
99.89
Solubility
Ethanol : 140 mg/mL (ultrasonic)
Smiles
O=C(OCC(CC)CCCC)/C=C/C1=CC=C(OC)C=C1
Molecular Formula
C18H26O3
Molecular Weight
290.40
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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