(+) -TK216

(+) -TK216 is an enantiomer of TK216 (HY-122903) . TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1][2].

Product Specifications

CAS Number

[1903783-77-6]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/plus-tk216.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C(Cl)=CC=C2Cl)C1(CC(C3=CC=C(C4CC4)C=C3)=O)O.[Rotation(+)]

Molecular Formula

C19H15Cl2NO3

Molecular Weight

376.23

References & Citations

[1]Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25 (16) :5167-5176.|[2]Jean-Michael Vernier, et al. Indolinone compounds and uses thereof. WO2016057698A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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