(+) -TK216
(+) -TK216 is an enantiomer of TK216 (HY-122903) . TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1][2].
Product Specifications
CAS Number
[1903783-77-6]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plus-tk216.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C(Cl)=CC=C2Cl)C1(CC(C3=CC=C(C4CC4)C=C3)=O)O.[Rotation(+)]
Molecular Formula
C19H15Cl2NO3
Molecular Weight
376.23
References & Citations
[1]Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25 (16) :5167-5176.|[2]Jean-Michael Vernier, et al. Indolinone compounds and uses thereof. WO2016057698A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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