(1R,2R) -2-PCCA (hydrochloride)

(1R,2R) -2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay.

Product Specifications

CAS Number

[1609563-71-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GPR88

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_1R,2R_-2-PCCA_hydrochloride_.html

Purity

98.08

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CCCC1=CC=C(C2=CC=C(N(C[C@@H](N)[C@@H](C)CC)C([C@H]3[C@H](C4=CC=CC=N4)C3)=O)C=C2)C=C1.[H]Cl.[H]Cl

Molecular Formula

C30H39Cl2N3O

Molecular Weight

528.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Bi, Yingzhi, et al. Modulators of G Protein-Coupled Receptor 88. US 20110251204 A1.|[2]Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7 (10) :1418-1432.|[3]Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5 (7) :576-87.