SLK/STK10-IN-1

SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with antitumor activity.

Product Specifications

CAS Number

[264210-49-3]

UNSPSC

12352005

Target

CDK; GSK-3; Ser/Thr Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/slk-stk10-in-1.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(NC1=CC=CC(Cl)=C1)=C2C3=CC=CC=C3OC)NC2=O

Molecular Formula

C17H13ClN2O3

Molecular Weight

328.75

References & Citations

[1]Serafim RAM, et al. Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. J Med Chem. 2021 Sep 23;64 (18) :13259-13278. |[2]Marshall-Burghardt S, et al., Excitable Rho dynamics control cell shape and motility by sequentially activating ERM proteins and actomyosin contractility. Sci Adv. 2024 Sep 6;10 (36) :eadn6858.|[3]Serafim RAM, et al., Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. J Med Chem. 2021 Sep 23;64 (18) :13259-13278.