P38 MAP Kinase Inhibitor III
P38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an 50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with 50 values of 0.37 μM and 0.044 μM, respectively[1].
Product Specifications
CAS Number
581098-48-8
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p38-map-kinase-inhibitor-iii.html
Purity
98.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H](NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)NC(SC)=N2)=C1)C4=CC=CC=C4
Molecular Formula
C23H21FN4S
Molecular Weight
404.50
References & Citations
[1]Stefan A Laufer, et al. Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46 (15) :3230-44.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38 MAPK
Available Sizes
Frequently Asked Questions
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