PE-Labeled Human CD30 / TNFRSF8 Protein, His Tag (Site-specific conjugation)

PE-Labeled Human CD30, His Tag (CD0-HP2E3) is produced via site-specific conjugation of PE to Human CD30, His Tag under optimal conditions with a proprietary technology. Human CD30, His Tag is expressed from human 293 cells (HEK293) . It contains AA Phe 19 - Lys 379 (Accession # NP_001234.2) .

Product Specifications

Background

Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. TNFRSF-8 is expressed by activated, but not by resting, T and B cells. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. CD30 is the receptor for TNFSF8/CD30L. CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 41.1 kDa.

Accession Number

P28908-1 (C297R)

Expression Region

Phe 19 - Lys 379

Host

HEK293

Target

CD30

Conjugation

PE Labeled

Tag

C-6xHis

Source

Human

Applications

Evaluation of anti-CD30 CAR expression by flow cytometry. Please note that this product is NOT compatible to streptavidin detection system.

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.