Dithranol
Dithranol (Anthralin) is an anthraquinone derivative, with potent anti-psoriatic effects. Dithranol can inhibit DNA replication and repair[1][2].
Product Specifications
CAS Number
1143-38-0
Product Name Alternative
Anthralin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Dithranol.html
Purity
98.0
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C=CC=C2O)CC3=CC=CC(O)=C13
Molecular Formula
C14H10O3
Molecular Weight
226.23
Precautions
H302, H315, H319, H335
References & Citations
[1]L Kemény , et al. Dithranol: a review of the mechanism of action in the treatment of psoriasis vulgaris. Skin Pharmacol. 1990;3 (1) :1-20.|[2]J M Clark, et al. Inhibition of DNA replication and repair by anthralin or danthron in cultured human cells. J Invest Dermatol. 1982 Jul;79 (1) :18-22.|[3]A Farkas, et al. Dithranol upregulates IL-10 receptors on the cultured human keratinocyte cell line HaCaT. Inflamm Res. 2001 Jan;50 (1) :44-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
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Available Sizes
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