Aristolochic acid A

Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1].

Product Specifications

CAS Number

[313-67-7]

Product Name Alternative

Aristolochic acid I; TR 1736

UNSPSC

12352005

Hazard Statement

H301, H340, H350

Target

NF-κB

Type

Natural Products

Related Pathways

NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aristolochic-acid-a.html

Purity

99.91

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

OC(C1=CC2=C(OCO2)C3=C4C(C(OC)=CC=C4)=CC([N+]([O-])=O)=C31)=O

Molecular Formula

C17H11NO7

Molecular Weight

341.27

Precautions

H301, H340, H350

References & Citations

[1]Huang YT, et al. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137.|[2]Chenchen Feng, et al. Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A. Environ Toxicol Pharmacol. 2013 Nov;36 (3) :850-7.|[3]Youjia Zeng, et al. Autophagy inhibitors promoted aristolochic acid I induced renal tubular epithelial cell apoptosis via mitochondrial pathway but alleviated nonapoptotic cell death in mouse acute aritolochic acid nephropathy model. Apoptosis. 2014 Aug;19 (8) :1215-24.