1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine

1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine is a phospholipids that contains stearic acid and oleic acid at the sn-1 and sn-2 positions, respectively. It has been used in the generation of lipid nanoparticles (LNPs) for in vitro delivery of mRNA or nuclear-targeted plasmid DNA.

Product Specifications

CAS Number

[6418-95-7]

Product Name Alternative

1-Stearoyl-2-Oleoyl-sn-glycero-3-PE; 18:0-18:1 PE; PE (18:0/18:1)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/1-stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(O)(OCCN)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

Molecular Formula

C41H80NO8P

Molecular Weight

746.05

Precautions

H302, H315, H319, H335

References & Citations

[1]Álvarez-Benedicto, E., Farbiak, L., Ramírez, M.M., et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA) . Biomater. Sci. 10 (2), 549-559 (2022) .|[2]Tanaka, H., Akita, H., Ishiba, R., et al. Neutral biodegradable lipid-envelope-type nanoparticle using vitamin A-Scaffold for nuclear targeting of plasmid DNA. Biomaterials 35 (5), 1755-1761 (2014) .