Aloesin

Aloesin (Aloeresin) is a tyrosinase inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research[1][2][3].

Product Specifications

CAS Number

[30861-27-9]

Product Name Alternative

Aloeresin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Tyrosinase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aloesin.html

Purity

99.62

Solubility

DMSO : 270 mg/mL (ultrasonic)

Smiles

OC1=CC(C)=C(C(C=C(CC(C)=O)O2)=O)C2=C1[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO

Molecular Formula

C19H22O9

Molecular Weight

394.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang LQ, et al. Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway. Anal Cell Pathol (Amst) . 2017;2017:8158254.|[2]Wahedi HM, et al. Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. Phytomedicine. 2017 May 15;28:19-26.|[3]Y H Jin, et al. Aloesin and arbutin inhibit tyrosinase activity in a synergistic manner via a different action mechanism. Arch Pharm Res. 1999 Jun;22 (3) :232-6.