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BAY-8400

BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM) . BAY-8400 can be used for the research of cancer[1].

Product Specifications

CAS Number

2763602-59-9

UNSPSC

12352005

Target

DNA-PK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bay-8400.html

Concentration

10mM

Purity

99.38

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(C1=CC(C2=CC=C3N=CC4=NN=C(N4C3=C2)C5=CCCOCC5)=CN=C1)F

Molecular Formula

C21H17F2N5O

Molecular Weight

393.39

References & Citations

[1]Berger M, et al. BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies [published online ahead of print, 2021 Aug 24]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00762.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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