BAY-8400
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM) . BAY-8400 can be used for the research of cancer[1].
Product Specifications
CAS Number
2763602-59-9
UNSPSC
12352005
Target
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-8400.html
Concentration
10mM
Purity
99.38
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(C1=CC(C2=CC=C3N=CC4=NN=C(N4C3=C2)C5=CCCOCC5)=CN=C1)F
Molecular Formula
C21H17F2N5O
Molecular Weight
393.39
References & Citations
[1]Berger M, et al. BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies [published online ahead of print, 2021 Aug 24]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00762.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
P017-568-125 1x 125 µL
CD81 (Mouse/Rat) Recombinant Monoclonal Hamster Antibody (24MS04.81), CF®568 Conjugate - Biotium Choice
Sign In for Pricing
View Details 
![Pleckstrin (PLEK) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI6H8]](https://cdn.genprice.uk/products/937/68dd1b65061270361ea142ff/imageurl/ta500903bm.webp)
TA500903BM 100 µL
Pleckstrin (PLEK) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI6H8]
Sign In for Pricing
View Details 
BNC882302-100 1x 100 µL
MUC18 / CD146 / MCAM (Melanoma Cell Adhesion Molecule) (rMUC18/1130), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![ABCF2 Mouse Monoclonal Antibody [Clone ID: OTI5D5]](https://cdn.genprice.uk/products/937/68dd18bb061270361e908aad/imageurl/cf811212.webp)