5α-Hydroxycostic acid
5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating VEGF/VEGFR2 and Ang2/Tie2 pathways[1].
Product Specifications
CAS Number
[132185-83-2]
UNSPSC
12352211
Target
VEGFR
Type
Natural Products
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5α-hydroxycostic-acid.html
Purity
95.17
Solubility
10 mM in DMSO
Smiles
O[C@]12[C@@](CC[C@H](C1)C(C(O)=O)=C)(CCCC2=C)C
Molecular Formula
C15H22O3
Molecular Weight
250.33
References & Citations
[1]Liang N, et, al. Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways. Int J Oncol. 2017 Jul;51 (1) :213-222.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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