5α-Hydroxycostic acid

5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating VEGF/VEGFR2 and Ang2/Tie2 pathways[1].

Product Specifications

CAS Number

[132185-83-2]

UNSPSC

12352211

Target

VEGFR

Type

Natural Products

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5α-hydroxycostic-acid.html

Purity

95.17

Solubility

10 mM in DMSO

Smiles

O[C@]12[C@@](CC[C@H](C1)C(C(O)=O)=C)(CCCC2=C)C

Molecular Formula

C15H22O3

Molecular Weight

250.33

References & Citations

[1]Liang N, et, al. Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways. Int J Oncol. 2017 Jul;51 (1) :213-222.