Dyrk1A-IN-4
Dyrk1A-IN-4 is a potent and orally active Dyrk1A inhibitor. Dyrk1A-IN-4 exhibits IC50s against DYRK1A and DYRK2 of 2 nM and 6 nM. Dyrk1A-IN-4 exhibits the inhibition of the DYRK1A pSer520 autophosphorylation in U2OS cells with an IC50 of 28 nM. Dyrk1A-IN-4 can be used for the studies of ovarian adenocarcinoma, neuroblastoma and cervical squamous cell carcinoma[1].
Product Specifications
CAS Number
[2091883-59-7]
UNSPSC
12352005
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dyrk1a-in-4.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(CN1C2=C(N=C1C)C=CC(C3=CC(N)=NC(N)=C3)=N2)F
Molecular Formula
C14H13F3N6
Molecular Weight
322.29
References & Citations
[1]Csaba Weber, et al. Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J Med Chem. 2021 May 27;64 (10) :6745-6764.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1; DYRK2
Available Sizes
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