DOTA-ADIBO (TFA)

DOTA-ADIBO TFA is a DOTA-derived bifunctional chelator (BFC) that allows drug conjugation via an uncatalyzed, copper-free cycloaddition reaction. DOTA-ADIBO TFA enables the construction of fusion chelator systems that can be further used to synthesize radiotracers after Cu[64] modification. Positron emission tomography imaging of tumors expressing integrin αvβ6[1].

Product Specifications

UNSPSC

12352200

Target

Integrin

Type

Biochemical Assay Reagents

Related Pathways

Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dota-adibo-tfa.html

Purity

99.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(CN1CCN(CC(O)=O)CCN(CC(NCCC(N2C3=C(C#CC4=C(C2)C=CC=C4)C=CC=C3)=O)=O)CCN(CC(O)=O)CC1)=O.O=C(O)C(F)(F)F

Molecular Formula

C36H43F3N6O10

Molecular Weight

776.76

References & Citations

[1]Siow et al. Chemical Modifications on the αvβ6 Integrin Targeting A20FMDV2 Peptide: A Review[J]. ChemMedChem, 2024: e202400131.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Isoform

αvβ6

Available Sizes

Curated Selection

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