8-Gingerol

8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.

Product Specifications

CAS Number

[23513-08-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Akt; Apoptosis; Autophagy; Bacterial; Caspase; EGFR; MMP; mTOR; PERK; PI3K; STAT; TRP Channel

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; JAK/STAT Signaling; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/8-gingerol.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CCCCCCC[C@H](O)CC(CCC1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C19H30O4

Molecular Weight

322.44

Precautions

H315, H319, H335

References & Citations

[1]Dedov, V.N., et al. Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br. J. Pharmacol. 137 (6), 793-798 (2002) .|[2]Chrubasik, S., et al. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12 (9), 684-701 (2005) .|[3]Hu SM, et al. 8‑Gingerol regulates colorectal cancer cell proliferation and migration through the EGFR/STAT/ERK pathway. Int J Oncol. 2020 Jan;56 (1) :390-397.|[4]Lu J, et al. Immunosuppressive activity of 8-gingerol on immune responses in mice. Molecules. 2011 Mar 22;16 (3) :2636-45.|[5]Xue Y, et al. 8-Gingerol Ameliorates Myocardial Fibrosis by Attenuating Reactive Oxygen Species, Apoptosis, and Autophagy via the PI3K/Akt/mTOR Signaling Pathway. Front Pharmacol. 2021 Jul 28;12:711701.