DS68591889

DS68591889 is a selective and orally active phosphatidylserine synthase 1 (PTDSS1) inhibitor. DS68591889 has no inhibitory activity against PTDSS2. DS68591889 induces the phospholipid imbalance in a wide range of cancer cells. DS68591889 negatively regulates B cell receptor (BCR) -induced Ca2+ signaling and subsequent apoptotic cell death. DS68591889 can be used for the cancer research, such as B cell lymphoma[1].

Product Specifications

CAS Number

[2488609-21-6]

UNSPSC

12352005

Target

Apoptosis; Phospholipase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ptdss1-in-1.html

Concentration

10mM

Purity

99.18

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C1OC2=C(C3=NNC4=C3C(C5=CC=C(C=C5)OC6=CC=C(C(C)=C6)OC(F)(F)F)N(CC(F)(C)F)C4=O)C=CC=C2N1

Molecular Formula

C29H21F5N4O5

Molecular Weight

600.49

References & Citations

[1]Omi J, et al. Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma. J Cell Biol. 2024 Feb 5;223 (2) :e202212074.