LPS-PG

Product Specifications

UNSPSC Description

LPS-PG is a lipopolysaccharide from Porphyromonas gingivalis (P. gingivalis). LPS-PG is an important virulence factor in the pathogenesis of periodontal disease and activates immune cells via Toll-like receptor 2 (TLR2), rather than the receptor for Escherichia coli (E. coli), Toll-like receptor 4 (TLR4). A lipoprotein from LPS-PG has been shown to be the major component responsible for TLR2-mediated cell activation[1][2].

Target Antigen

MyD88; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lps-pg.html

Smiles

[LPS-PG]

References & Citations

[1]Park CM, et al. Chlorogenic Acid as a Positive Regulator in LPS-PG-Induced Inflammation via TLR4/MyD88-Mediated NF-κB and PI3K/MAPK Signaling Cascades in Human Gingival Fibroblasts. Mediators Inflamm. 2022 Apr 9;2022:2127642.|[2]Hashimoto M,et al. Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalis[J]. International immunology, 2004, 16(10): 1431-1437.