MAChR antagonist 1
MAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively[1].
Product Specifications
CAS Number
[101491-79-6]
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/machr-antagonist-1.html
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1CCC(CC1)OC(N(C2=CC=CC=C2)C3=CC=CC=C3)=O
Molecular Formula
C19H22N2O2
Molecular Weight
310.39
References & Citations
[1]Marlon Millard, et al. Design, synthesis and preclinical evaluation of muscarine receptor antagonists via a scaffold-hopping approach. Eur J Med Chem. 2023 Oct 21:262:115891.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1; mAChR2; mAChR3; mAChR4; mAChR5
Available Sizes
Curated Selection
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