Dinoprost (tromethamine salt)

Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL) . Dinoprost tromethamine salt plays a key role in the onset and progression of labour[1][2].

Product Specifications

CAS Number

[38562-01-5]

Product Name Alternative

Prostaglandin F2α (tromethamine salt) ; PGF2α THAM; Prostaglandin F2α THAM

UNSPSC

12352211

Hazard Statement

H302, H360

Target

Apoptosis; Autophagy; Endogenous Metabolite; Prostaglandin Receptor

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Dinoprost-tromethamine-salt.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL

Smiles

CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(O)=O.OCC(CO)(N)CO

Molecular Formula

C24H45NO8

Molecular Weight

475.62

Precautions

H302, H360

References & Citations

[1]Hagen Thieme, et al. Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. Invest Ophthalmol Vis Sci. 2006 Mar;47 (3) :938-45.|[2]Xin Wen, et al. Prostaglandin F2α Induces Goat Corpus Luteum Regression via Endoplasmic Reticulum Stress and Autophagy. Front Physiol. 2020 Sep 11;11:868.