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CC-885

CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 is also a known degrader of GSPT1, inhibiting protein translation.

Product Specifications

CAS Number

1010100-07-8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for E3 Ligase; Molecular Glues

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CC-885.html

Purity

99.85

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)NC4=CC=C(C)C(Cl)=C4

Molecular Formula

C22H21ClN4O4

Molecular Weight

440.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Mary E. Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature. 2016 Jul 14;535 (7611) :252-7.|[2]Jochem M, et al. Degradome analysis to identify direct protein substrates of small-molecule degraders[J]. bioRxiv, 2024: 2024.01. 28.577572.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Available Sizes

Frequently Asked Questions

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