(E/Z) -Ensifentrine

(E/Z) -Ensifentrine is a dual inhibitor of PDE3/4. (E/Z) -Ensifentrine reduces the inflammatory cells into the airways. (E/Z) -Ensifentrine has bronchodilatory and anti-inflammatory activities in vitro and in vivo model[1].

Product Specifications

CAS Number

[298680-25-8]

Product Name Alternative

(E/Z) -RPL-554

UNSPSC

12352005

Hazard Statement

H315-H335-H361-H373

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e-z-ensifentrine.html

Solubility

10 mM in DMSO

Smiles

O=C(N)NCCN1C(N(CCC2=C3C=C(OC)C(OC)=C2)C3=C/C1=N\C4=C(C)C=C(C)C=C4C)=O

Molecular Formula

C26H31N5O4

Molecular Weight

477.56

Precautions

P260-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P403+P233-P405-P501

References & Citations

[1]Page CP, et al. Phosphodiesterase inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. Int Arch Allergy Immunol. 2014;165 (3) :152-64.