Oncrasin-1

Oncrasin-1 is an RNA polymerase inhibitor. Oncrasin-1 suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. Oncrasin-1 effectively kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 leads to coaggregation of PKCι and splicing factors into megaspliceosomes. Oncrasin-1 induces malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can therefore be studied in research for lung cancer[1][2].

Product Specifications

CAS Number

[75629-57-1]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Apoptosis; DNA/RNA Synthesis; Ras

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Oncrasin-1.html

Concentration

10mM

Purity

98.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31

Molecular Formula

C16H12ClNO

Molecular Weight

269.73

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Guo W, et al. Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. Cancer Res. 2008 Sep 15;68 (18) :7403-8.|[2]Guo W, et al. Interruption of RNA processing machinery by a small compound, 1-[ (4-chlorophenyl) methyl]-1H-indole-3-carboxaldehyde (oncrasin-1) . Mol Cancer Ther. 2009 Feb;8 (2) :441-8.