Amsacrine

Amsacrine (m-AMSA; acridinyl anisidide) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.

Product Specifications

CAS Number

[51264-14-3]

Product Name Alternative

M-AMSA; acridinyl anisidide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H350, H360

Target

Autophagy; Topoisomerase

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Amsacrine.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CS(=O)(NC1=CC=C(NC2=C(C=CC=C3)C3=NC4=CC=CC=C42)C(OC)=C1)=O

Molecular Formula

C21H19N3O3S

Molecular Weight

393.46

Precautions

H302, H315, H319, H335, H350, H360

References & Citations

[1]Thomas D, et al. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142 (3) :485-94.|[2]Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33 (6) :426-33.|[3]Kao-Shan CS, et al. Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro. Cancer Treat Rep. 1984 Jul-Aug;68 (7-8) :989-97.|[4]Lee YC, et al. Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. Apoptosis. 2016 Oct 19