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4-​Hydroxyphenylpyruvic acid

4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase. 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria[1][2].

Product Specifications

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-_4-Hydroxyphenyl_-2-oxopropanoic_acid.html

Concentration

10mM

Purity

99.04

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)C(CC1=CC=C(O)C=C1)=O

Molecular Formula

C9H8O4

Molecular Weight

180.16

Precautions

H315, H319

References & Citations

[1]Brand LM, et al. Effect of glucagon on phenylalanine metabolism and phenylalanine-degrading enzymes in the rat. Biochem J. 1974 Aug;142 (2) :231-45.|[2]Tomoeda K, et al. Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria. Mol Genet Metab. 2000 Nov;71 (3) :506-10.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-W010040/4-Hydroxyphenylpyruvic-acid-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-W010040/4-Hydroxyphenylpyruvic-acid-SDS-MedChemExpress.pdf

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite; Microbial Metabolite

CAS Number

[156-39-8]

Available Sizes

Curated Selection

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