1- (Isothiazol-3-yl) ethan-1-one

1- (Isothiazol-3-yl) ethan-1-one (Q11) is a CYP2E1 inhibitor. 1- (Isothiazol-3-yl) ethan-1-one can be used in rheumatoid arthritis and sepsis related research[1].

Product Specifications

CAS Number

[88511-35-7]

Product Name Alternative

1- (Isothiazol-3-yl) ethanone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1-isothiazol-3-yl-ethan-1-one.html

Purity

99.2600

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C1=NSC=C1)=O

Molecular Formula

C5H5NOS

Molecular Weight

127.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Han Z, et al. Discovery of CYP2E1 as a novel target in rheumatoid arthritis and validation by a new specific CYP2E1 inhibitor. Biochem Pharmacol. 2024 Aug 20;229:116501. |[2]Han Z, et al. Discovery of CYP2E1 as a novel target in rheumatoid arthritis and validation by a new specific CYP2E1 inhibitor. Biochem Pharmacol. 2024 Aug 20;229:116501. |[3]Gao N, et al. The CYP2E1 inhibitor Q11 ameliorates LPS-induced sepsis in mice by suppressing oxidative stress and NLRP3 activation. Biochem Pharmacol. 2023 Aug;214:115638.