Mcl-1 inhibitor 20
Mcl-1 inhibitor 20 (compound 47) is a Mcl-1 inhibitor with anti-leukemic effects. Mcl-1 inhibitor 20 can bind to the BH3 binding groove of Mcl-1 (Ki=24 nM), occupy the P1 pocket in Mcl-1, and form interactions with Lys234 and Val249. Mcl-1 inhibitor 20 has good microsomal stability, pharmacokinetic characteristics and low cardiotoxicity[1].
Product Specifications
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcl-1-inhibitor-20.html
Smiles
O=C(C(N1CCN2CCOCC2)=C(CCCOC3=CC(C)=C(Cl)C(C)=C3)C4=C1C(C5=CC=CC=C5CN6C=C(CCN(CCN7CCOCC7)S(C8=CC=C(F)C=C8)(=O)=O)C9=C6C=CC=C9)=CC=C4)O
Molecular Formula
C55H61ClFN5O7S
Molecular Weight
990.62
References & Citations
[1]Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1H-indole-1-yl Moiety Binding to the P1–P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
More Discoveries
Explore Other Products
Browse additional items from our catalog
![ANKMY2 Mouse Monoclonal Antibody [Clone ID: OTI1H4]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
TA507327S 30 µL
ANKMY2 Mouse Monoclonal Antibody [Clone ID: OTI1H4]
Sign In for Pricing
View Details 
bs-9261R-BF680 100 µL
RNF185 Polyclonal Antibody, AbBy Fluor™ 680 Conjugated
Sign In for Pricing
View Details MBS7035064-01 0.02 mg
Recombinant Bacillus subtilis Uncharacterized protein yitM (yitM)
Sign In for Pricing
View Details 
MBS7035064-02 0.1 mg
Recombinant Bacillus subtilis Uncharacterized protein yitM (yitM)
Sign In for Pricing
View Details MBS7035064-03 5x 0.1 mg
Recombinant Bacillus subtilis Uncharacterized protein yitM (yitM)
Sign In for Pricing
View Details