Mcl-1 inhibitor 20

Mcl-1 inhibitor 20 (compound 47) is a Mcl-1 inhibitor with anti-leukemic effects. Mcl-1 inhibitor 20 can bind to the BH3 binding groove of Mcl-1 (Ki=24 nM), occupy the P1 pocket in Mcl-1, and form interactions with Lys234 and Val249. Mcl-1 inhibitor 20 has good microsomal stability, pharmacokinetic characteristics and low cardiotoxicity[1].

Product Specifications

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mcl-1-inhibitor-20.html

Smiles

O=C(C(N1CCN2CCOCC2)=C(CCCOC3=CC(C)=C(Cl)C(C)=C3)C4=C1C(C5=CC=CC=C5CN6C=C(CCN(CCN7CCOCC7)S(C8=CC=C(F)C=C8)(=O)=O)C9=C6C=CC=C9)=CC=C4)O

Molecular Formula

C55H61ClFN5O7S

Molecular Weight

990.62

References & Citations

[1]Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1H-indole-1-yl Moiety Binding to the P1–P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells