Mcl-1 inhibitor 20
Product Specifications
UNSPSC Description
Mcl-1 inhibitor 20 (compound 47) is a Mcl-1 inhibitor with anti-leukemic effects. Mcl-1 inhibitor 20 can bind to the BH3 binding groove of Mcl-1 (Ki=24 nM), occupy the P1 pocket in Mcl-1, and form interactions with Lys234 and Val249. Mcl-1 inhibitor 20 has good microsomal stability, pharmacokinetic characteristics and low cardiotoxicity[1].
Target Antigen
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/mcl-1-inhibitor-20.html
Smiles
O=C(C(N1CCN2CCOCC2)=C(CCCOC3=CC(C)=C(Cl)C(C)=C3)C4=C1C(C5=CC=CC=C5CN6C=C(CCN(CCN7CCOCC7)S(C8=CC=C(F)C=C8)(=O)=O)C9=C6C=CC=C9)=CC=C4)O
Molecular Weight
990.62
References & Citations
[1]Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1H-indole-1-yl Moiety Binding to the P1–P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159588/Mcl-1-inhibitor-20-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159588/
Clinical Information
No Development Reported
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