Pritelivir-d4-1
Pritelivir-d4-1 (AIC316-d4-1) is deuterium labeled Pritelivir. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2[1][2].
Product Specifications
Product Name Alternative
AIC316-d4-1; BAY 57-1293-d4-1
UNSPSC
12352005
Target
HSV; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
O=C(N(C1=NC(C)=C(S1)S(N)(=O)=O)C)CC2=CC=C(C=C2)C3=C(C([2H])=C(C([2H])=N3)[2H])[2H]
Molecular Formula
C18H14D4N4O3S2
Molecular Weight
406.52
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Ligat G, et al. Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-PrimaseComplex. Front Microbiol. 2018 Oct 23;9:2483.|[3]Wald A, et al. Helicase-primase inhibitor Pritelivir for HSV-2 infection. N Engl J Med. 2014 Jan 16;370 (3) :201-10.|[4]Quenelle DC, et al. Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. Antiviral Res. 2018 Jan;149:1-6.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
IGMNCYWBK2E100ML 100 mL
Innovative Grade US Origin Monkey Cynomolgus Whole Blood K2 EDTA 100ml
Sign In for Pricing
View Details 
MOFY-0922-FY150 Each
Mouse Anti-B. aboRoom Temperatureus LPS Antibody, IgG1 (MOFY-0922-FY150)
Sign In for Pricing
View Details 
K1654504 1.0 µg DNA
PIWIL1 sgRNA CRISPR Lentivector (Human) (Target 3)
Sign In for Pricing
View Details orb2619914 100 µg
Lymphotactin/XCL1 Rabbit Polyclonal Antibody (Cy3)
Sign In for Pricing
View Details 
VAng-Lsx06311-500gEcoli 500 µg (E. coli)
Recombinant Mycoplasma Capricolum rpsQ Protein (aa 1-85)
Sign In for Pricing
View Details